Effects of Sinapic Acid of 4 Vessel Occlusion Model-Induced Ischemia and Cognitive Impairments in the Rat
Clinical Psychopharmacology and Neuroscience
;
: 86-90, 2011.
Article
in English
| WPRIM
| ID: wpr-127841
ABSTRACT
OBJECTIVE:
Sinapic acid (SA, Sinapine), small naturally occurring hydroxycinnamic acid, has a GABA(A) receptor agonistic property and free radical scavenging activity. We examined potential neuroprotective effects of sinapic acid (SA) using global cerebral ischemia animal model.METHODS:
MTT assay was performed to determine cytotoxic effects of SA. To examine the neuroprotective effects of SA, SA was administrated for 14 d before 4-vessel occlusion. Also, to determine whether SA prevents cognitive impairment, Morris water maze was performed.RESULTS:
In this study, the efficacy of SA for the prevention of neuronal damage and for the reduction of memory impairment was investigated.CONCLUSION:
The results indicate that SA confers significant neuroprotection especially for ischemic hippocampal neurons.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Brain Ischemia
/
Receptors, GABA-A
/
Neuroprotective Agents
/
Maze Learning
/
Coumaric Acids
/
Glycosaminoglycans
/
Hippocampus
/
Ischemia
/
Memory
/
Neurons
Limits:
Animals
Language:
English
Journal:
Clinical Psychopharmacology and Neuroscience
Year:
2011
Type:
Article
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