Characteristics of Tuberculosis Detected during Chemotherapy for a Solid Tumor / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
; : 285-290, 2005.
Article
in Ko
| WPRIM
| ID: wpr-128729
Responsible library:
WPRO
ABSTRACT
BACKGROUND: Some malignancies including lymphoma, head and neck cancer, and lung cancer are believed to be associated with the reactivation of tuberculosis (TB) because cyclic anti-cancer chemotherapy can induce the leukopenia or immunological deterioration. This report describes the clinical characteristics and treatment response of TB that developed during cyclic anti-cancer chemotherapy in patients with a solid tumor. MATERIALS AND METHODS: From January 1 2000 to July 31 2004, patients with TB diagnosed microbiologically, pa?thologically, or clinically during anti-cancer chemotherapy in a tertiary hospital were enrolled, and their medical records were reviewed. Patients with the known risk factors for the reactivation of TB were excluded. RESULTS: Twenty-two patients were enrolled and their mean age was 56.5 years (range 21-78). The male to female ratio was 3.4:1 and pulmonary TB was the main variant (20 patients, 90.9%). Gastric cancer (10 patients, 45.4%) and lymphoma (4 patients, 18.2%) were the leading underlying malignancies. The other malignancies included lung cancer, head and neck cancer, breast cancer, cervix cancer, and ovary cancer. Fifteen patients (68.2%) had a healed scar on a simple chest radiograph suggesting a previous TB infection. Among these patients, new TB lesions involved the same lobe or the ipsilateral pleura in 13 patients (87.6%). An isoniazid and rifampicin based regimen were started in all the subjects except for one patient with a hepatic dysfunction. The mean duration of medication was 9.9 +/- 2.4 months and no adverse events resulting in a regimen change were observed. With the exception of 5 patients who died of the progression of the underlying malignancy, 70.6% (12/17) completed the anti-TB treatment. CONCLUSION: The clinical characteristics and response to anti-TB treatment for TB that developed during anti- cancer chemotherapy for a solid tumor were not different from those of patients who developed TB in the general population.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Ovarian Neoplasms
/
Pleura
/
Rifampin
/
Stomach Neoplasms
/
Tuberculosis
/
Breast Neoplasms
/
Radiography, Thoracic
/
Uterine Cervical Neoplasms
/
Medical Records
/
Risk Factors
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
Language:
Ko
Journal:
Tuberculosis and Respiratory Diseases
Year:
2005
Type:
Article