Effect of Cocoa Extract on Tension of the Corpus Cavernosal Tissue in Rat / 대한남성과학회지
Korean Journal of Andrology
; : 115-122, 2008.
Article
in Ko
| WPRIM
| ID: wpr-134467
Responsible library:
WPRO
ABSTRACT
PURPOSE:
Cocoa has antihypertensive activity, improves cerebral blood flow, and is an antioxidant. We evaluated the effect of cocoa extract on penile erection using the relaxation of the corpus cavernosal tissue in rat. MATERIALS ANDMETHODS:
We used male 8-week-old Sprague-Dawley rats weighting 250-350 g divided into three groups corpus cavernosal tissue with the endothelium (group 1), tissue without the endothelium (group 2), and endothelium pretreated with L-NAME (group 3). Changes in isometric tension were examined in an organ bath. Aortic tissues were divided into three groups and treated in similar experiments simultaneously.RESULTS:
Cocoa extract dose-dependently relaxed corpus cavernosal tissue pre-contracted by phenylephrine (10-6). In group 1, cocoa extract (10-3g/ml) induced relaxation by 97+/-5% (mean+/-SD). The extract was still effective but less potent tissue without endothelium or pretreated with L-NAME (10-4M). Similar effects were seen in aortic rings.CONCLUSION:
Cocoa extract relaxes corpus cavernosal tissue in a dose-dependent manner via NOS and the endothelium. Cocoa extract may therefore be effective for improving erectile function.Key words
Full text:
1
Index:
WPRIM
Main subject:
Phenylephrine
/
Relaxation
/
Baths
/
Penile Erection
/
Cacao
/
Rats, Sprague-Dawley
/
NG-Nitroarginine Methyl Ester
/
Endothelium
Limits:
Animals
/
Humans
/
Male
Language:
Ko
Journal:
Korean Journal of Andrology
Year:
2008
Type:
Article