The effects of intravenous dexmedetomidine on spinal anesthesia: comparision of different dose of dexmedetomidine / 대한마취과학회지
Korean Journal of Anesthesiology
; : 252-257, 2014.
Article
in En
| WPRIM
| ID: wpr-136231
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
In this prospective, randomized, double-blind, placebo-controlled trial, we tried to find out appropriate amounts of single-dose dexmedetomidine to prolong the duration of spinal anesthesia in a clinical setting.METHODS:
Sixty patients who were scheduled for unilateral lower limb surgery under spinal anesthesia were randomized into three groups receiving normal saline (control group, n = 20) or 0.5 or 1.0 ug/kg dexmedetomidine (D-0.5 group, n = 20; D-1, n = 20) intravenously prior to spinal anesthesia with 12 mg of bupivacaine. The two-dermatome pinprick sensory regression time, duration of the motor block, Ramsay sedation score (RSS), and side effects of dexmedetomidine were assessed.RESULTS:
The two-dermatome pinprick sensory regression time (57.6 +/- 23.2 vs 86.5 +/- 24.3 vs 92.5 +/- 30.7, P = 0.0002) and duration of the motor block (98.8 +/- 34.1 vs 132.9 +/- 43.4 vs 130.4 +/- 50.4, P = 0.0261) were significantly increased in the D-0.5 and D-1 groups than in the control group. The RSS were significantly higher in the D-0.5 and D-1 groups than in the control group. However, there were no patients with oxygen desaturation in dexmedetomidine groups. The incidences of hypotension and bradycardia showed no differences among the three groups.CONCLUSIONS:
Both 0.5 and 1.0 ug/kg of dexmedetomidine administered as isolated boluses in the absence of maintenance infusions prolonged the duration of spinal anesthesia.Key words
Full text:
1
Index:
WPRIM
Main subject:
Oxygen
/
Bradycardia
/
Bupivacaine
/
Incidence
/
Prospective Studies
/
Dexmedetomidine
/
Lower Extremity
/
Hypotension
/
Anesthesia, Spinal
Type of study:
Clinical_trials
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Korean Journal of Anesthesiology
Year:
2014
Type:
Article