Clinical implications of DMSA Scan in Childhood Acute Pyelonephritis
Childhood Kidney Diseases
; : 107-113, 2017.
Article
in En
| WPRIM
| ID: wpr-136727
Responsible library:
WPRO
ABSTRACT
PURPOSE:
This study aimed to evaluate the relationships between 99mTecnicium-dimercaptosuccinic acid (DMSA) scan findings and clinical parameters including age and fever duration.METHODS:
The positive rates for abnormal DMSA scans were analyzed according to the age of patients, fever duration prior to admission, and total fever duration. DMSA scan findings were divided into 3 categories single defect, multifocal defects, and discrepant defects. We evaluated the detection rates of vesicoureteral reflux according to DMSA scan lesions.RESULTS:
Among a total 320 cases, 141 (44.1%) had abnormal DMSA scans. The infant group (0-1 year of age) had a shorter total fever duration, and a lower C-reactive protein (CRP) value and DMSA positive rate (39.8% vs. 60.6%, P=0.002) compared to children group (2-15 years of age). Patients with abnormal scans had a longer total fever duration and higher CRP compared to those with normal scans. The positivity rate of abnormal scans did not differ between the patients with a short fever duration prior to admission of ≤2 days and those with longer fever duration of ≥3 days. However, patients with longer total fever duration had a higher rate of abnormal DMSA scans (P=0.02). Among cases with a single defect, multifocal defects, and discrepant defects, vesicoureteral reflux was observed in 22.4%, 60% and 70.6% of cases, respectively (P=0.004).CONCLUSION:
Although DMSA scan has limitations in early diagnosis, DMSA scan findings may aid in the prediction of the severity of systemic inflammation and detection of vesicoureteral reflux.Key words
Full text:
1
Index:
WPRIM
Main subject:
Pyelonephritis
/
Urinary Tract Infections
/
Vesico-Ureteral Reflux
/
C-Reactive Protein
/
Succimer
/
Early Diagnosis
/
Fever
/
Inflammation
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Limits:
Child
/
Humans
/
Infant
Language:
En
Journal:
Childhood Kidney Diseases
Year:
2017
Type:
Article