Clinicopathological Characteristics in Invasive Ductal Breast Cancer with Low FDG Uptake in (18)F-FDG PET/CT / 한국유방암학회지

ABSTRACT

PURPOSE: The aim of this study is to evaluate whether low FDG uptake would be associated with the biological low-aggressiveness of invasive ductal carcinoma. METHODS: The subjects consisted of 124 female patients with primary invasive ductal carcinoma. All the patients were examined with (18)F-FDG PET/CT before neoadjuvant chemotherapy. RESULTS: With regard to histopathologic grading, 117 were histopathologic grade 1 and 2, and 7 were grade 3. Low FDG uptake correlated with well and moderate histopathologic grade (p=0.003) and low (18)F-FDG uptake in invasive ductal carcinoma depended on the presence of axillary lymph node metastases (p=0.014) and small tumor (<2.0 cm, p=0.022). Ki-67 positivity ranged from 0% to 60% (mean 15%). Sixty seven specimens showed low immunoreactivity to Ki-67 antigen (<10% of tumor cells). This revealed a significant correlation between low FDG uptake and Ki-67 (p=0.003). Logistic regression analysis between these factors showed that lower histologic grade, no axillary lymph nodes metastases and low Ki-67 (<10%) were correlated with low FDG uptake. CONCLUSION: Our results demonstrated that an association exists between low FDG uptake and good prognostic factors such as lower histologic grade (1, 2), no axillary lymph node metastases and low Ki-67 (<10%).