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Formulation and Evaluation of Irinotecan Suppository for Rectal Administration
Article in En | WPRIM | ID: wpr-138503
Responsible library: WPRO
ABSTRACT
Irinotecan suppository was prepared using the moulding method with a homogeneous blend. A sensitive and specific fluorescence method was developed and validated for the determination of irinotecan in plasma using HPLC. The pharmacokinetics of intravenous administered and rectal administered in rabbits was investigated. Following a single intravenous dose of irinotecan (50 mg/kg), the plasma irinotecan concentration demonstrated a bi-exponential decay, with a rapid decline over 15 min. C(max), t(1/2), AUC(0-30h) and AUC(0-infinity) were 16.1 +/- 2.7 g/ml, 7.6 +/- 1.2 h, 71.3 +/- 8.8 microg.h/ml and 82.3 +/- 9.5 microg.h/ml, respectively. Following rectal administration of 100 mg/kg irinotecan, the plasma irinotecan concentration reached a peak of 5.3 +/- 2.5 microg/ml at 4 h. The AUC(0-30h) and AUC(0-infinity) were 32.2 +/- 6.2 microg.h/ml and 41.6 +/- 7.2 microg.h/ml, respectively. It representing ~50.6% of the absolute bioavailability.
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Full text: 1 Index: WPRIM Main subject: Plasma / Administration, Rectal / Pharmacokinetics / Biological Availability / Chromatography, High Pressure Liquid / Fluorescence Limits: Animals Language: En Journal: Biomolecules & Therapeutics Year: 2014 Type: Article
Full text: 1 Index: WPRIM Main subject: Plasma / Administration, Rectal / Pharmacokinetics / Biological Availability / Chromatography, High Pressure Liquid / Fluorescence Limits: Animals Language: En Journal: Biomolecules & Therapeutics Year: 2014 Type: Article