Optimal method for early detection of cardiac disorders in thalassemia major patients: magnetic resonance imaging or echocardiography?
Blood Research
; : 182-186, 2014.
Article
in En
| WPRIM
| ID: wpr-145978
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Heart failure resulting from myocardial iron deposition is the most important cause of death in beta-thalassemia major (TM) patients. Cardiac T2*magnetic resonance imaging (MRI), echocardiography, and serum ferritin level serve as diagnostic methods for detecting myocardial iron overload. In this study, we aimed to evaluate the relationship between the above-mentioned methods.METHODS:
T2*MRI and echocardiographic measurement of left ventricular (LV) systolic and diastolic function were performed in 63 patients. Serum ferritin level was measured. The relationships between all assessments were evaluated.RESULTS:
There were 40 women and 23 men with a mean age of 23.7+/-5.1 years (range, 15-35 years). There was no statistically significant correlation between serum ferritin level and LV systolic and diastolic function (P=0.994 and P=0.475, respectively). T2*MRI results had a significant correlation with ferritin level; 63.6% of patients with serum ferritin level >2,000 ng/mL had abnormal cardiac MRI, while none of the patients with ferritin level <1,000 ng/mL had abnormal cardiac MRI (P=0.001). There was no significant correlation between MRI findings and LV systolic function (P=1.00). However, we detected a significant difference between LV diastolic function and cardiac siderosis (P=0.03)CONCLUSION:
MRI findings are a good predictor of future cardiac dysfunction, even in asymptomatic TM patients; however, diastolic dysfunction may happen prior to cardiac siderosis in some patients, and echocardiography is able to diagnose this diastolic dysfunction while T2*MRI shows normal findings.Key words
Full text:
1
Index:
WPRIM
Main subject:
Magnetic Resonance Imaging
/
Echocardiography
/
Siderosis
/
Cause of Death
/
Beta-Thalassemia
/
Iron Overload
/
Ferritins
/
Heart Failure
/
Iron
Type of study:
Diagnostic_studies
/
Screening_studies
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Blood Research
Year:
2014
Type:
Article