A Prospective, Randomized Comparison of Promus Everolimus-Eluting and TAXUS Liberte Paclitaxel-Eluting Stent Systems in Patients with Coronary Artery Disease Eligible for Percutaneous Coronary Intervention: The PROMISE Study
Journal of Korean Medical Science
; : 1609-1614, 2013.
Article
in En
| WPRIM
| ID: wpr-148469
Responsible library:
WPRO
ABSTRACT
We aimed comparing two-year clinical outcomes of the Everolimus-Eluting Promus and Paclitaxel-Eluting TAXUS Liberte stents used in routine clinical practice. Patients with objective evidence of ischemia and coronary artery disease eligible for PCI were prospectively randomized to everolimus-eluting stent (EES) or paclitaxel-eluting stent (PES) groups. The primary end-point was ischemia-driven target vessel revascularization (TVR) at 2 yr after intervention, and the secondary end-point was a major adverse cardiac event (MACE), such as death, myocardial infarction (MI), target lesion revascularization (TLR), TVR or stent thrombosis. A total of 850 patients with 1,039 lesions was randomized to the EES (n=425) and PES (n=425) groups. Ischemic-driven TVR at 2 yr was 3.8% in the PES and 1.2% in the EES group (P for non-inferiority=0.021). MACE rates were significantly different; 5.6% in PES and 2.5% in EES (P = 0.027). Rates of MI (0.8% in PES vs 0.2% in EES, P = 0.308), all deaths (1.5% in PES vs 1.2% in EES, P = 0.739) and stent thrombosis (0.3% in PES vs 0.7% in EES, P = 0.325) were similar. The clinical outcomes of EES are superior to PES, mainly due to a reduction in the rate of ischemia-driven TVR.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Thrombosis
/
Coronary Artery Disease
/
Prospective Studies
/
Treatment Outcome
/
Paclitaxel
/
Sirolimus
/
Coronary Restenosis
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Drug-Eluting Stents
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Percutaneous Coronary Intervention
/
Immunosuppressive Agents
Type of study:
Clinical_trials
/
Observational_studies
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2013
Type:
Article