Therapeutic Effect of Different Doses of Recombinant Human Granulocyte Colony-Stimulating Factor(rhG-CSF) on Neonatal Sepsis Complicated by Neutropenia
Journal of the Korean Pediatric Society
;
: 439-448, 2002.
Article
in Korean
| WPRIM
| ID: wpr-150342
ABSTRACT
PURPOSE:
The aim of this study is to determine and compare the effects of adjunctive therapy with different doses of recombinant human granulocyte-colony stimulating factor(rhG-CSF) on reversing sepsis-associated neonatal neutropenia, and their survival rate in a group I/II-type trial.METHODS:
RhG-CSF was injected subcutaneously to 10 septic-neutropenic neonates with doses of 10 microgram/kg from Oct. 1995 to Sep. 1996, and was administered to another 12 septic-neutropenic neonates with doses of 5 microgram/kg from Oct. 1996 to Sep. 1997. Neutrophilic responses and the outcomes of both groups were compared.RESULTS:
In the rhG-CSF 10 microgram/kg treated group and in the 5 microgram/kg treated group, the absolute neutrophil count(ANC) was 1,065+/-89(mean+/-SEM) and 1,053+/-131, respectively. The only difference between the two groups was the peak ANC at 48 hours. Eight patients from the remaining nine of rhG-CSF 10 microgram/kg treated group(88.9%) and ten in 5 microgram/kg treated group(83.3%) survived the sepsis and were discharged without any problems.CONCLUSIONS:
RhG-CSF can increase the neutrophil count in critically ill septic neutropenic neonats. The survival rate of both groups were up to 90%. This finding suggests that both doses of rhG-CSF may be effective in a therapeutically useful time frame to treat septic neonates with neonatal neutropenia attributable to bone marrow supression or neutrophil consumption.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bone Marrow
/
Survival Rate
/
Critical Illness
/
Sepsis
/
Granulocytes
/
Neutropenia
/
Neutrophils
Limits:
Humans
/
Infant, Newborn
Language:
Korean
Journal:
Journal of the Korean Pediatric Society
Year:
2002
Type:
Article
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