Potentiation by Propranolol of the Skeletal Neuromuscular Block Caused by Rocuronium / 대한마취과학회지
Korean Journal of Anesthesiology
; : 315-319, 2008.
Article
in Ko
| WPRIM
| ID: wpr-151689
Responsible library:
WPRO
ABSTRACT
BACKGROUND: Propranolol potentiates the effect of neuromuscular blocking agents and induces myasthenic syndromes through curare-like and local anesthetic activities.The purpose of this study was to determine if propranolol potentiated the neuromuscular block caused by rocuronium during both single (0.1 Hz) and tetanic stimulation (50 Hz for 1.9 seconds). METHODS: Left phrenic nerve-hemidiaphragms (Male Sprague-Dawley rats, 150-250 g) were mounted in Krebs solution, and three consecutive single twitches and one tetanic tension were obtained prior to each treatment. Each preparation was exposed to one of 4 propranolol concentrations (0, 1.0, 2.5, 5micrometer), 5micrometer propranolol with 2micrometer norepinephrine or 2micrometer norepinephrine alone and the concentration of rocuronium was then increased cumulatively until a 80% reduction of single twitch occurred.The effects of the drugs used were allowed to reach a steady state by waiting for 20 minutes at each concentration before measuring the tension. Effective concentrations of rocuronium at each treatment were calculated using a probit model.Differences between treatments were tested with student's t-test and Bonferroni's correction with a P < 0.05 being regarded as significant. RESULTS: The neuromuscular block caused by rocuronium was augmented by propranolol, however the augmentation caused by propranolol was not reversed by norepinephrine. CONCLUSIONS: The results of this study indicate that the potentiation by propranolol of the neuromuscular block caused by rocuronium is independent of its adrenoceptor blocking action.
Key words
Full text:
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Index:
WPRIM
Main subject:
Propranolol
/
Norepinephrine
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Rats, Sprague-Dawley
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Neuromuscular Blockade
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Androstanols
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Isotonic Solutions
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Neuromuscular Blocking Agents
Language:
Ko
Journal:
Korean Journal of Anesthesiology
Year:
2008
Type:
Article