Herpes Simplex Encephalitis after Concurrent Chemoradiotherapy in Nasopharyngeal Cancer: A Case Report / 대한내과학회지
Korean Journal of Medicine
; : 602-607, 2015.
Article
in Ko
| WPRIM
| ID: wpr-152296
Responsible library:
WPRO
ABSTRACT
Herpes simplex encephalitis (HSE) is a rare viral encephalitis in adults. A high (70%) mortality rate with serious complications has been reported even after active, appropriate management. The association between HSE and immune suppression is unclear, but there are case reports of cancer patients in which HSE concomitantly developed after whole brain radiation or high-dose steroid treatment. The clinical manifestations and laboratory findings of these patients are atypical compared to the general population. Although brain magnetic resonance images reveal typical HSE findings, cerebrospinal fluid (CSF) analysis might be normal in cancer patients. We report a case of HSE in a 48-year-old male diagnosed with nasopharyngeal cancer and treated with concurrent chemoradiation. This patient had a normal cell count in CSF, but HSE was finally diagnosed from positive polymerase chain reaction test results. After administration of acyclovir and systemic steroid treatment, the patient had a good clinical course with few neurologic sequelae.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Brain
/
Acyclovir
/
Cell Count
/
Cerebrospinal Fluid
/
Nasopharyngeal Neoplasms
/
Polymerase Chain Reaction
/
Mortality
/
Encephalitis, Viral
/
Encephalitis, Herpes Simplex
/
Chemoradiotherapy
Type of study:
Prognostic_studies
Limits:
Adult
/
Humans
/
Male
Language:
Ko
Journal:
Korean Journal of Medicine
Year:
2015
Type:
Article