Meta-analysis of Circulating Adiponectin, Visfatin, and Ghrelin Levels in Patients with Systemic Lupus Erythematosus
Journal of Rheumatic Diseases
;
: 99-107, 2017.
Article
in English
| WPRIM
| ID: wpr-15464
ABSTRACT
OBJECTIVE:
To evaluate the association between circulating adiponectin, visfatin, and ghrelin levels and systemic lupus erythematosus (SLE).METHODS:
We conducted a meta-analysis to compare serum/plasma adiponectin, visfatin, and ghrelin levels in patients with SLE to those of healthy controls.RESULTS:
Eleven articles (822 patients with SLE and 676 controls) were included in the meta-analysis. The meta-analysis showed that the adiponectin level was significantly higher in the SLE group than in the control group (standardized mean difference [SMD]=0.360, 95% confidence interval [CI]=0.025∼0.695, p=0.035). Stratification according to region showed that high adiponectin levels were associated with SLE in the Western population (SMD=0.225, 95% CI=0.024∼0.426, p=0.028), but not in the South American population. A subgroup analysis that adiponectin level is significantly higher in the SLE group than in the control after adjustment for age, sex, body mass index, large sample size (n>100); and mean age>40 years (SMD=0.492, 95% CI=0.065∼0.920, p=0.024; SMD=0.492, 95% CI=0.065∼0.920, p=0.024; SMD=0.429, 95% CI=0.124∼0.733, p=0.006, respectively). Stratification by region showed significantly increased visfatin and ghrelin levels in the SLE group in Western and South American populations.CONCLUSION:
Our meta-analysis demonstrated that circulating adiponectin, visfatin, and ghrelin levels are significantly higher in SLE.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Body Mass Index
/
Sample Size
/
Adiponectin
/
Ghrelin
/
Nicotinamide Phosphoribosyltransferase
/
Lupus Erythematosus, Systemic
Type of study:
Systematic reviews
Limits:
Humans
Language:
English
Journal:
Journal of Rheumatic Diseases
Year:
2017
Type:
Article
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