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Cell cycle checkpoint control
Experimental & Molecular Medicine ; : 1-11, 1997.
Article in English | WPRIM | ID: wpr-15746
ABSTRACT
Genetic instability is considered to be a major driving force of malignancy of cancer cells, and at least some of cancer-associated genetic instability is known to be caused by defects in the cell cycle checkpoint control. Patients of the cancer-prone genetic disorder ataxia telangiectagia frequently develop malignant lymphoma and their cells are defective in gamma-irradiation responsive checkpoint control, whereas cells inactivated for the p53 recessive oncoprotein are defective in DNA damage-induced checkpoint control and develop genetic instability. Cells contain two major cell cycle checkpoint control systems DNA-replication checkpoint, DNA-damage checkpoint. These checkpoint systems are thought to consist of three functionally distinct components sensors, checkpoint signal transducers and cell cycle effecters. Recent rapid progress in the identification of these components is beginning to prove this conceptual model and the generality of the checkpoint system among eukaryotes. The full understanding of the cell cycle checkpoint control system will provide deeper insights into the highly complex mechanisms of carcinogenesis and highlight possible targets for cancer therapy.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Ataxia / Transducers / DNA Damage / DNA / Cell Cycle / DNA Replication / Eukaryota / Cell Cycle Checkpoints / Carcinogenesis / Lymphoma Limits: Humans Language: English Journal: Experimental & Molecular Medicine Year: 1997 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Ataxia / Transducers / DNA Damage / DNA / Cell Cycle / DNA Replication / Eukaryota / Cell Cycle Checkpoints / Carcinogenesis / Lymphoma Limits: Humans Language: English Journal: Experimental & Molecular Medicine Year: 1997 Type: Article