Effect of Trans-4-Aminomethylcyclohexanecarboxylic Acid on the Proliferation and Melanization in Cultured Normal Human Melanocytes
Annals of Dermatology
; : 60-67, 2007.
Article
in En
| WPRIM
| ID: wpr-158870
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Trans-4-aminomethylcyclohexanecarboxylic acid (tranexamic acid) has recently been reported to inhibit prostaglandin synthesis and hinder the pigmentation caused after UV radiation.OBJECTIVE:
we evaluated the influence of tranexamic acid on the viability, morphogenesis and melanization of cultured normal human melanocytes.METHOD:
The cultured melanocytes from neonatal foreskin were exposed to UVB 20mJ/cm2, then treated with tranexamic acid [0.05microgram/ml, 0.05microgram/ml, and 0.5microgram/ml]. After 24 hours, the viability of melanocytes and the melanin concentration was measured. The number and length of the melanocytes' dendrites, and the expression level of tyrosinase, TRP-1 and TRP-2 were also evaluated.RESULTS:
The viability of the melanocytes was decreased by tranexamic acid in a dose dependent manner (p<0.05). The increased melanin synthesis by UVB irradiation was decreased by tranexamic acid in a dose dependent manner (p<0.05). Also, the increased expressions of TRP-1, TRP-2 and tyrosinase after exposure to UV were statistically decreased by tranexamic acid in a dose dependent manner (p<0.05).CONCLUSION:
tranexamic acid may prevents UVB induced pigmentation.Key words
Full text:
1
Index:
WPRIM
Main subject:
Tranexamic Acid
/
Pigmentation
/
Monophenol Monooxygenase
/
Dendrites
/
Foreskin
/
Melanins
/
Melanocytes
/
Morphogenesis
Limits:
Humans
Language:
En
Journal:
Annals of Dermatology
Year:
2007
Type:
Article