The Effects of Vasopressin and Desmopressin on the Contractile and Relaxation Responses of Rabbit Cavernosal Smooth Muscle / 대한비뇨기과학회지
Korean Journal of Urology
;
: 366-372, 2008.
Article
in Korean
| WPRIM
| ID: wpr-159178
ABSTRACT
PURPOSE:
This study aimed to investigate the effects of vasopressin and desmopressin on the contractile and relaxative responses of rabbit cavernosal smooth muscle. MATERIALS ANDMETHODS:
Isometric tension studies were conducted to investigate the effects of vasopressin(10(-14)-10(-8)M) and desmopressin(10(-14)- 10(-8)M) on the contraction and relaxation responses of rabbits cavernous muscle strips in an organ bath. The effects of pretreatment with phenylephrine(10(-5)M), L-NAME(10(-5)M) and indomethacin(10(-5)M) on the contraction and relaxation responses of the vasopressin and desmopressin were also investigated. The statistics were analyzed by Student's t-test and ANOVA.RESULTS:
Vasopressin contracted the strips in a dose-dependent manner, while desmopressin did not. The phenylephrine-induced contraction was dose-dependently increased by vasopressin, but it was dose-dependently relaxed by desmopressin. L-NAME pre-treatment did not block the relaxation response, but indomethacin pre-treatment did. Vasopressin- induced contraction occurred the via V(1) receptor, while desmopressin- induced relaxation occurred via the V(2) receptor.CONCLUSIONS:
Vasopressin, in pathophysiological circumstances, would worsen erectile dysfunction. On the contrary, desmopressin, which may induce an endothelium-dependent relaxation of the cavernous smooth muscles, would be good for erectile function.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Relaxation
/
Baths
/
Vasopressins
/
Indomethacin
/
NG-Nitroarginine Methyl Ester
/
Contracts
/
Deamino Arginine Vasopressin
/
Caves
/
Erectile Dysfunction
/
Muscle, Smooth
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Urology
Year:
2008
Type:
Article
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