Outcomes after bleomycin, etoposide and cisplatin combination chemotherapy in patients with ovarian yolk sac tumor / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
; : 1007-1013, 2010.
Article
in Ko
| WPRIM
| ID: wpr-159536
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
The aim of this study was to evaluate the oncologic and reproductive outcomes of patients with ovarian yolk sac tumor after bleomycin, etoposide, cisplatin (BEP) chemotherapy following surgery.METHODS:
Of 145 patients with histologically confirmed malignant ovarian germ cell tumor, 43 had yolk sac tumor and received BEP chemotherapy after surgery. A retrospective analysis of these patients was performed.RESULTS:
The mean age of 43 patients was 24.8 years (range, 7 to 59 years). Thirty eight patients were nulliparous. Of 179 BEP chemotherapy cycles, grade 1~2 hematologic and non-hematologic adverse events occurred in 46 cycles in 21 patients. Thirty nine patients showed complete remission, 1 patient showed partial remission, and 3 patient had progressive disease during BEP chemotherapy. After median follow-up time of 57 months (range, 3 to 153 months), 5 patients had recurrent disease and three of them died of disease. The 5-year recurrence free survival rate and overall survival rate were 86% and 94%, respectively. After chemotherapy, all but one premenarchal patients had normal menstruation. Of them 5 patients tried to conceive and 3 of them succeeded in pregnancy.CONCLUSION:
BEP chemotherapy was very safe and effective in patients with ovarian yolk sac tumor. Survival outcomes are excellent and reproductive outcomes are promising after BEP chemotherapy.Key words
Full text:
1
Index:
WPRIM
Main subject:
Recurrence
/
Yolk Sac
/
Bleomycin
/
Survival Rate
/
Retrospective Studies
/
Follow-Up Studies
/
Cisplatin
/
Endodermal Sinus Tumor
/
Neoplasms, Germ Cell and Embryonal
/
Drug Therapy, Combination
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Pregnancy
Language:
Ko
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2010
Type:
Article