Effect of Obesity on Prostate-Specific Antigen, Prostate Volume, and International Prostate Symptom Score in Patients with Benign Prostatic Hyperplasia
Korean Journal of Urology
;
: 401-405, 2011.
Article
in English
| WPRIM
| ID: wpr-159624
ABSTRACT
PURPOSE:
We examined the correlation between body mass index (BMI) as a marker of obesity and prostate-specific antigen (PSA), prostate volume (PV), and International Prostate Symptom Score (IPSS) in patients with benign prostatic hyperplasia (BPH). MATERIALS ANDMETHODS:
From January 2008 to December 2008, we examined 258 patients diagnosed with BPH. Patients taking 5alpha-reductase inhibitors or those diagnosed with prostate cancer were excluded from this study. BPH was defined as PV> or =25 ml and IPSS> or =8. BMI (kg/m2) was categorized into 4 groups as follows BMI27.5 (obese). The relationships between PSA, PV, IPSS, and BMI were analyzed by correlation analysis and one-way ANOVA.RESULTS:
The mean age of the patients was 65.19+/-9.13 years and their mean BMI was 23.7+/-4.4 kg/m2. The mean PSA values of each BMI group were as follows 3.42+/-1.53, 3.07+/-1.88, 2.74+/-1.75, and 2.60+/-1.44 ng/ml. The PSA value was lowest in the obese group. The correlation analysis showed a negative correlation between BMI and PSA (Pearson's correlation coefficient=-0.142, p=0.023) and positive correlations between BMI and PV (Pearson's correlation coefficient=0.32, p=0.001) and IPSS (Pearson's correlation coefficient=0.470, p=0.02). These correlations were also confirmed by one-way ANOVA.CONCLUSIONS:
Patients with an elevated BMI tended to have lower PSA values, larger PVs, and a higher IPSS. We suggest that weight loss could be helpful for BPH symptom relief as well as for detection of coexisting prostate cancer in BPH patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostate
/
Prostatic Hyperplasia
/
Prostatic Neoplasms
/
Weight Loss
/
Body Mass Index
/
Analysis of Variance
/
Prostate-Specific Antigen
/
Obesity
Type of study:
Diagnostic study
Limits:
Humans
Language:
English
Journal:
Korean Journal of Urology
Year:
2011
Type:
Article
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