The Effect of Phosphodiesterase-4-Specific Inhibitor in the Rat Model of Spinal Nerve Ligation
Journal of Korean Neurosurgical Society
;
: 109-113, 2011.
Article
in English
| WPRIM
| ID: wpr-16217
ABSTRACT
OBJECTIVE:
Peripheral neuropathy is characterized by hyperalgesia, spontaneous burning pain, and allodynia. The purpose of this study was to investigate the effect of rolipram, a phosphodiesterase-4-specific inhibitor, in a segmental spinal nerve ligation model in rats.METHODS:
Both the L5 and L6 spinal nerves of the left side of the rats were ligated. Phosphodiesterase-4 inhibitor (rolipram) and saline (vehicle) were administered intraperitoneally. We measured mechanical allodynia using von Frey filaments and a nerve conduction study.RESULTS:
The mechanical allodynia, which began to manifest on the first day, peaked within 2 days. Multiple intraperitoneal injections of rolipram ameliorated the mechanical allodynia. Furthermore, an intraperitoneal administration of rolipram improved the development of pain behavior and nerve conduction velocity.CONCLUSION:
This study suggests that the phosphodiesterase-4 inhibitor, rolipram, alleviates mechanical allodynia induced by segmental spinal nerve ligation in rats. This finding may have clinical implications.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spinal Nerves
/
Burns
/
Peripheral Nervous System Diseases
/
Rolipram
/
Cyclic Nucleotide Phosphodiesterases, Type 4
/
Peripheral Nerve Injuries
/
Hyperalgesia
/
Injections, Intraperitoneal
/
Ligation
/
Neural Conduction
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Journal of Korean Neurosurgical Society
Year:
2011
Type:
Article
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