Effect of Adenine on Clozapine-induced Neutropenia in Patients with Schizophrenia: A Preliminary Study
Clinical Psychopharmacology and Neuroscience
;
: 157-162, 2015.
Article
in English
| WPRIM
| ID: wpr-162187
ABSTRACT
OBJECTIVE:
This study examined the utility of adenine for preventing clozapine-induced neutropenia.METHODS:
This retrospective study examined the effect of adenine on clozapine-induced neutropenia in patients with treatment-resistant schizophrenia and was conducted at Okehazama Hospital in Japan from July 2010 to June 2013. Adenine was available for use from June 2011 onwards. Twenty-one patients started receiving clozapine treatment from July 2010 to April 2011 (the pre-adenine adoption group), and 47 patients started receiving it from May 2011 to June 2013 (the post-adenine adoption group). The effects of adenine were assessed based on changes in the patients' leukocyte counts and the frequency of treatment discontinuation due to clozapine-induced neutropenia.RESULTS:
Sixty-eight patients were treated with clozapine from July 2010 to June 2013. Of the 21 patients in the pre-adenine adoption group, 4 discontinued treatment due to clozapine-induced neutropenia, whereas only 2 of the 47 patients in the post-adenine adoption group discontinued treatment. The frequency of treatment discontinuation due to clozapine-induced neutropenia was significantly lower in post-adenine adoption group than in the pre-adenine adoption group (p=0.047).CONCLUSION:
Adenine decreased the frequency of treatment discontinuation due to clozapine-induced neutropenia. Our data suggest that combined treatment with clozapine and adenine is a safe and effective strategy against treatment-resistant schizophrenia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Schizophrenia
/
Adenine
/
Retrospective Studies
/
Clozapine
/
Japan
/
Leukocyte Count
/
Neutropenia
Type of study:
Observational study
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Clinical Psychopharmacology and Neuroscience
Year:
2015
Type:
Article
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