Histomorphologic Changes of the Contralateral Testis in Unilateral Inguinal Cryptorchidism / 대한비뇨기과학회지
Korean Journal of Urology
; : 427-434, 2001.
Article
in Ko
| WPRIM
| ID: wpr-163532
Responsible library:
WPRO
ABSTRACT
PURPOSE: The pathogenesis of infertility in unilateral cryptorchidism remains unclear. We studied prospectively to evaluate the cause concerning potential infertility in unilateral inguinal cryptorchidism.Materials and Methods: Between Feb 1998 and July 2000, 30 specimens were taken by ipsilateral undescended and contralateral descened testicular biopsies in 15 unilateral inguinal cryptorchid boys (age range: 1-11 years, mean: 4.7 years). Control testicular biopsies were performed in 5 hydrocele boys (age range: 1-9 years, mean: 5.1 years). We performed histomorphologic analysis including spermatogonia per tubule (S/T) value, Sertoli cell index (SCI), tubular degeneration phase V-VII (TDP V-VII), mean tubular diameter (MTD), and changes of peritubular interstitial tissue (thickened tubular basement membrane and peritubular fibrosis). RESULTS: Testis volume, S/T value, and MTD were significantly different between ipsilateral cryptorchid and contralateral testes. However, there was no significant difference between ipsilateral cryptorchid and contralateral testis in SCI, TDP V-VII, and changes of peritubular interstitial tissue. We found significant difference between contralateral and control testis in testis volume, S/T value, MTD, TDP V-VII, and changes of peritubular interstitial tissue except SCI.Conclusions: Decreased testis volume, S/T value, MTD and increased TDP V-VII of contralateral testis are associated with germinal hypoplasia. These findings may explain the pathogenesis of infertility in unilateral inguinal cryptorchidism.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Spermatogonia
/
Testis
/
Basement Membrane
/
Biopsy
/
Prospective Studies
/
Cryptorchidism
/
Infertility
Type of study:
Observational_studies
Language:
Ko
Journal:
Korean Journal of Urology
Year:
2001
Type:
Article