Stevens-Johnson Syndrome Induced by Vandetanib
Annals of Dermatology
; : S343-S345, 2011.
Article
in En
| WPRIM
| ID: wpr-165614
Responsible library:
WPRO
ABSTRACT
Vandetanib is a once-daily oral anticancer drug that selectively inhibits key signaling pathways in cancer by targeting vascular endothelial growth factor receptors, epidermal growth factor receptors tyrosine kinase, and rearranged during transfection-dependent tumor cell proliferation and survival. The most frequently reported adverse events attributed to vandetanib include diarrhea, elevated aminotransferase, asymptomatic corrected QT interval prolongation, and hypertension. Though a number of randomized, doubleblind studies, including cutaneous adverse events attributed to vandetanib, have been reported along with these general symptoms, no case of Stevens-Johnson syndrome (SJS) has been reported. This paper demonstrates a case of SJS induced by vandetanib.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Piperidines
/
Quinazolines
/
Protein-Tyrosine Kinases
/
Stevens-Johnson Syndrome
/
Carcinoma, Non-Small-Cell Lung
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Receptors, Vascular Endothelial Growth Factor
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Cell Proliferation
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Diarrhea
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ErbB Receptors
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Hypertension
Type of study:
Clinical_trials
Language:
En
Journal:
Annals of Dermatology
Year:
2011
Type:
Article