Lymph node metastasis and pattern of recurrence in clinically early stage endometrial cancer with positive lymphovascular space invasion / 부인종양
Journal of Gynecologic Oncology
; : 208-213, 2015.
Article
in En
| WPRIM
| ID: wpr-165919
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To investigate the rate, predictors of lymph node metastasis (LNM) and pattern of recurrence in clinically early stage endometrial cancer (EC) with positive lymphovascular space invasion (LVSI).METHODS:
Women with clinically early stage EC and positive LVSI 2005 to 2012 were identified. Kaplan-Meier curves and logistic regression models were used.RESULTS:
One hundred forty-eight women were identified. Of them, 25.7% had LNM (21.7% pelvic LNM, 18.5% para-aortic LNM). Among patients with LNM who had both pelvic and para-aortic lymphadenectomy, isolated pelvic, para-aortic and both LNM were noted in 51.4%, 17.1%, and 31.4% respectively. Age and depth of myometrial invasion were significant predictors of LNM in LVSI positive EC. Node positive patients had high recurrence rate (47% vs. 11.8%, p<0.05) especially distant (60.9% vs. 7.9%, p<0.001) and para-aortic (13.2% vs. 1.8%, p=0.017) recurrences compared to node negative EC. LNM was associated with lower progression-free survival (p=0.002) but not overall survival (p=0.73).CONCLUSION:
EC with positive LVSI is associated with high risk of LNM. LNM is associated with high recurrence rate especially distant and para-aortic recurrences. Adjuvant treatments should target prevention of recurrences in these areas.Key words
Full text:
1
Index:
WPRIM
Main subject:
Retrospective Studies
/
Treatment Outcome
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Endometrial Neoplasms
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Disease-Free Survival
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Chemoradiotherapy, Adjuvant
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Lymph Node Excision
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Lymphatic Metastasis
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Neoplasm Invasiveness
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Neoplasm Recurrence, Local
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Aged
/
Female
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Humans
Language:
En
Journal:
Journal of Gynecologic Oncology
Year:
2015
Type:
Article