Multifactorial Regulation of G Protein-Coupled Receptor Endocytosis
Biomolecules & Therapeutics
; : 26-43, 2017.
Article
in En
| WPRIM
| ID: wpr-165940
Responsible library:
WPRO
ABSTRACT
Endocytosis is a process by which cells absorb extracellular materials via the inward budding of vesicles formed from the plasma membrane. Receptor-mediated endocytosis is a highly selective process where receptors with specific binding sites for extracellular molecules internalize via vesicles. G protein-coupled receptors (GPCRs) are the largest single family of plasma-membrane receptors with more than 1000 family members. But the molecular mechanisms involved in the regulation of GPCRs are believed to be highly conserved. For example, receptor phosphorylation in collaboration with β-arrestins plays major roles in desensitization and endocytosis of most GPCRs. Nevertheless, a number of subsequent studies showed that GPCR regulation, such as that by endocytosis, occurs through various pathways with a multitude of cellular components and processes. This review focused on i) functional interactions between homologous and heterologous pathways, ii) methodologies applied for determining receptor endocytosis, iii) experimental tools to determine specific endocytic routes, iv) roles of small guanosine triphosphate-binding proteins in GPCR endocytosis, and v) role of post-translational modification of the receptors in endocytosis.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Phosphorylation
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Binding Sites
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Glycosylation
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Cell Membrane
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Protein Processing, Post-Translational
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Cooperative Behavior
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Endocytosis
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Lipoylation
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Guanosine
Limits:
Humans
Language:
En
Journal:
Biomolecules & Therapeutics
Year:
2017
Type:
Article