Effect of ApoE Genotype on the Relationship between Nutritional Risk and Cognition in the Elderly
Journal of the Korean Geriatrics Society
; : 177-185, 2006.
Article
in Ko
| WPRIM
| ID: wpr-167575
Responsible library:
WPRO
ABSTRACT
BACKGROUND: The purpose of this study is to find out the effect of ApoE genotype on the relationship between nutritional risk and cognition of the elderly in a community. METHODS: A total of 996 subjects (343 men and 653 women) aged 60~91 years were analyzed from preliminary data of GDEMCIS (Gwangju Dementia and MCI Study). The study questionnaire consisted of demographic characteristics, current and past illness history, drug history, K-SGDS (Korean version of Short Form Geriatric Depression Scale), K-MMSE (Korean version-Mini Mental State Examina- tion), and NSI (Nutritional Screening Initiative) checklist. We also examined blood pressure, fasting serum glucose, lipid profile, body mass index, and ApoE genotyping. RESULTS: 649 subjects (65.2%) were on good nutritional state (NSI score or = 3). On multiple logistic regression analysis, moderate or high nutritional risk was associated with an increa- sed risk for cognitive impairment (K-MMSE score < or = 17) after adjustment with age, sex, K-GDS and educational level in the absence of ApoE epsilon4 allele (OR 1.78, 95% CI 1.15-2.77). CONCLUSION: These results suggest that nutritional risk may be associated with cognitive function in the elderly only in the absence of ApoE epsilon4 allele.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Apolipoproteins E
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Blood Glucose
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Blood Pressure
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Body Mass Index
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Logistic Models
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Mass Screening
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Surveys and Questionnaires
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Fasting
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Cognition
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Dementia
Type of study:
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Limits:
Aged
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Humans
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Male
Language:
Ko
Journal:
Journal of the Korean Geriatrics Society
Year:
2006
Type:
Article