The Enhancing Effect of Ethanol on the Development of Glutatione S-Transferase Placental Form-Positive Foci Induced by Diethylnitrosamine in F344 Rat
Journal of Korean Medical Science
; : 13-17, 1990.
Article
in En
| WPRIM
| ID: wpr-170678
Responsible library:
WPRO
ABSTRACT
The effects of ethyl alcohol and pig serum administration on the development of preneoplastic hepatic enzyme-altered foci were examined in an in vivo mid-term assay system. Rats were initially given a single dose (200 mg/Kg) intraperitoneal injection of diethylnitrosamine (DEN). Two weeks later, treatment was started with 10% ethanol + 10% sucrose solution, 10% sucrose solution, or tap water as drinking water for 6 weeks with or without intraperitoneal injection of porcine serum twice a week. All rats were subjected to a two-thirds partial hepatectomy at week 3. The modification potentials were evaluated by comparing the number and area per cm2 of glutathione S-transferase placental form-positive (GST-P+) foci in the liver of each group. As a result, ethanol significantly enhanced the development of GST-P+ foci. Unfortunately, the porcine serum injection produced no hepatic fibrosis and no significant alteration in GST-P+ foci.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Placenta
/
Precancerous Conditions
/
Rats, Inbred F344
/
Swine
/
Survival Rate
/
Diethylnitrosamine
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Ethanol
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Glutathione Transferase
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Immune Sera
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Liver Cirrhosis, Alcoholic
Limits:
Animals
Language:
En
Journal:
Journal of Korean Medical Science
Year:
1990
Type:
Article