Does ductal lavage assert its role as a noninvasive diagnostic modality to identify women at low risk of breast cancer development? / 부인종양
Journal of Gynecologic Oncology
; : 110-114, 2012.
Article
in En
| WPRIM
| ID: wpr-17307
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
Ductal lavage (DL) involves evaluation of the ductal system of the breast for detection of intra-ductal carcinomas and precursor lesions by collecting breast epithelial cells using a small-gauge catheter inserted into a ductal orifice on the nipple. The aim of this survey was to analyze cytologic features of samples obtained from low-risk women with DL and to elucidate the efficacy of this diagnostic modality in evaluating fluid production, cannulating and determining atypical breast epithelial cells.METHODS:
Into this prospective study were consecutively registered 80 women between ages 28 to 67. Nipple aspiration was performed to identify all fluid-yielding ducts. According to the grading of specific features the interpretation of the sample included normal/benign (category, 0), mild atypical (category, I), markedly atypical (category, II) or malignant (category, III) disorders.RESULTS:
Ninety five percent (316/334) of the nipple aspirate fluid samples were classified as category 0, 4.8% (16/334) as category I and 0.2% (2/334) as category II changes. Category III disorders were not detected. Therefore, in 80% of the women examined results were within normal limits while 17.5% of the participants presented mild atypical and 2.5% markedly atypical rates.CONCLUSION:
DL collection procedure proved to be rapid as well as acceptable by the women studied. It retains the advantage over other methods of nipple aspirate fluid in that it is easy to perform, thereby removing most clinician variability. It also helped low risk women to discriminate those with breast disorders that require additional investigation, further follow-up or administration of preventive medication.Key words
Full text:
1
Index:
WPRIM
Main subject:
Breast
/
Breast Neoplasms
/
Prospective Studies
/
Epithelial Cells
/
Nipple Aspirate Fluid
/
Catheters
/
Imidazoles
/
Therapeutic Irrigation
/
Nipples
/
Nitro Compounds
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
Language:
En
Journal:
Journal of Gynecologic Oncology
Year:
2012
Type:
Article