Clinicial Outcome of Pregnancies with Positive or Equivocal Anti-rubella IgM Antibody and Comparison of the Results Performed by 4 Different Enzyme Immunoassays / 대한임상병리학회지
Korean Journal of Clinical Pathology
; : 187-192, 2001.
Article
in Ko
| WPRIM
| ID: wpr-175079
Responsible library:
WPRO
ABSTRACT
BACKGROUND: The test for the anti-rubella IgM Ab (R-IgM) is important in early pregnancies because therapeutic termination may be considered depending on the results. METHODS: The subjects consisted of 52 pregnant women with positive or equivocal R-IgM by Cobas Core Anti-Rubella IgM EIA test (Roche, Basel, Swiss) between January 1997 and July 2000. Three different EIA methods such as the Enzygnost Anti-Rubella-virus/IgM test (DADE Behring, Marburg, Germany), the AxSYM Anti-Rubella IgM test (Abbott, USA), and the IMx Anti-Rubella IgM test (Abbott, USA) were simultaneously performed on 44 specimens as well as the Cobas Core Anti-Rubella IgM EIA test. RESULTS: Among 52 pregnancies, 9 (17%) experienced an artificial abortion due to positive or equivocal R-IgM result. The clinical symptoms associated with rubella infection were observed in 3 cases and the persistent R-IgM positivity was noted for more than 1 year in 4 cases. The concordance rate between 4 different EIAs was 41%. When performed with serial diluted pool and 3 sera, the results of Cobas Core were similar to those of AxSYM, IMx and Enzygnost. The R-IgM were detected one titre higher in diluted sera performed by IMx and Enzygnost than those of Cobas Core and AxSYM. CONCLUSIONS: For pregnancies with positive or equivocal R-IgM, it is recommended that results should be interpreted with caution, considering the possibilities, such as a persistent R-IgM response and discrepant R-IgM depending on the different EIA methods.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Rubella
/
Immunoglobulin M
/
Immunoenzyme Techniques
/
Pregnant Women
Limits:
Female
/
Humans
/
Pregnancy
Language:
Ko
Journal:
Korean Journal of Clinical Pathology
Year:
2001
Type:
Article