A Case of Miliary Brain Metastasis of Lung Cancer Mimicking Neurocysticercosis / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
; : 182-186, 2012.
Article
in Ko
| WPRIM
| ID: wpr-177717
Responsible library:
WPRO
ABSTRACT
Miliary brain metastasis from the lung is uncommon and has a poor therapeutic response. We report a case of pulmonary adenocarcinoma combined with multiple brain cystic lesions that were initially misdiagnosed as neurocysticercosis. A 53-year-old male who never smoked was admitted to our hospital with complaints of agitation and cognitive impairment. Brain magnetic resonance imaging showed innumerable, small nodular lesions with a central, low signal intensity in whole brain parenchyma. His symptoms were not improved by the empirical praziquantel medication for disseminated neurocysticercosis. After a transbronchial biopsy from the right middle lobe, we could diagnose the primary lung adenocarcinoma with a single nucleotide polymorphism in the epidermal growth factor receptor exon 20 at codon 787 (Q787Q). His neurologic symptoms and imaging findings have been gradually improving with a first-line Gefitinib treatment for five months. We recommend a more active diagnostic approach including biopsy in case of atypical imaging findings.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Praziquantel
/
Quinazolines
/
Smoke
/
Biopsy
/
Brain
/
Codon
/
Magnetic Resonance Imaging
/
Adenocarcinoma
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Exons
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Neurocysticercosis
Limits:
Humans
/
Male
Language:
Ko
Journal:
Tuberculosis and Respiratory Diseases
Year:
2012
Type:
Article