Evaluation of Endotheial Function in Normal Korean Adults and in Patients with Essential Hypertension
Journal of the Korean Society of Echocardiography
;
: 59-70, 2000.
Article
in Korean
| WPRIM
| ID: wpr-180714
ABSTRACT
BACKGROUND AND OBJECTIVES:
Flow-mediated brachial artery vasoactivity has been recently proposed as a noninvasive means for assessing endotheial function. This endothelial function is impaired in certain cardiovascular conditions, including essential hypertension.METHODS:
The study population included 50 healthy subjects aged 22 to 62 years (mean+/-SD, 42+/-12 years), all normotensive, nondiabetic with cholesterol level 0.05). 4) Flow-mediated dilatation was significantly lower in patients with essential hypertension than in normotensive control subjects (4.2+/-0.8 vs. 7.3+/-1.3 %, p0.05).CONCLUSIONS:
The study demonstrated that 1) in men older than 40 years, flow-mediated, endothelium-dependent vasodilation of the brachial artery was declined, 2) longer brachial artery occlusion resulted in more vasodilation despite similar hyperemic responses, 3) using low (30 mm Hg higher than systolic pressure) and high (70-90 mm Hg higher than systolic pressure) pressure, each pressure of occlusion was similar hyperemic response, and 4) in patients with essential hypertension, flow-medeiated vasodilation was significantly impaired and IMT was increased than in normotensive control subjects.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arm
/
Vascular Diseases
/
Vasodilation
/
Blood Pressure
/
Brachial Artery
/
Carotid Arteries
/
Cholesterol
/
Ultrasonography
/
Nitroglycerin
/
Carotid Artery, Common
Type of study:
Diagnostic study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Korean
Journal:
Journal of the Korean Society of Echocardiography
Year:
2000
Type:
Article
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