In Vitro Effects of Some Herbs Used in Egyptian Traditional Medicine on Viability of Protoscolices of Hydatid Cysts
The Korean Journal of Parasitology
;
: 255-263, 2011.
Article
in English
| WPRIM
| ID: wpr-182108
ABSTRACT
The present work evaluated the effects of alcoholic extracts of salvia (Salvia officinalis), thyme (Thymus vulgaris), and 2 pure compounds (thymol and menthol) on the viability of Echinococcus granulosus protoscolices in vitro. Four different concentrations of each extract (2,500, 1,500, 1,000, and 500 microg/ml) and 3 different concentrations each of thymol and menthol (50, 10, and 1 microg/ml) were used. Concentration of 2,500 microg/ml of both extracts showed a significant protoscolicidal activity on the 6th day. Complete loss of viability of protoscolices occurred with 500 microg/ml concentration of both extracts at day 6 and day 7 post-treatment (PT), respectively. Pure compounds, i.e., menthol and thymol, showed potent effects with 50 microg/ml concentration at day 2 and day 5 PT, respectively. These effects were compared with those of albendazole sulfoxide (800 microg/ml), a commonly used treatment drug for hydatidosis. Krebs-Ringer solution and the hydatid cystic fluid at a ratio of 41 was a good preservative solution which kept the protoscolices viable for 15 days.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Time Factors
/
Camelus
/
Plant Extracts
/
Cell Survival
/
Salvia officinalis
/
Echinococcus granulosus
/
Thymus Plant
/
Echinococcosis, Pulmonary
/
Lung
Limits:
Animals
Language:
English
Journal:
The Korean Journal of Parasitology
Year:
2011
Type:
Article
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