TERT Polymorphism rs2853669 Influences on Lung Cancer Risk in the Korean Population
Journal of Korean Medical Science
;
: 1423-1428, 2015.
Article
in English
| WPRIM
| ID: wpr-183079
ABSTRACT
Short telomeres are known as one of the risk factors for human cancers. The present study was conducted to evaluate the association between 6 polymorphisms, which were related with short telomere length in the Korean population, and lung cancer risk using 1,100 cases and 1,096 controls. Among the 6 polymorphisms, TERT rs2853669 was significantly associated with increased lung cancer risk under a recessive model (odds ratio [OR]=1.38, 95% confidence interval [CI]=1.05-1.81, P=0.02). The effect of rs2853669 on lung cancer risk was significant in younger individuals (OR=1.73, 95% CI=1.18-2.54, P=0.005) and adenocarcinoma (OR=1.50, 95% CI=1.07-2.07, P=0.02). Our results suggest that a common functional promoter polymorphism, TERT rs2853669, may influence both telomere length and lung cancer risk in the Korean population.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Adenocarcinoma
/
Case-Control Studies
/
Promoter Regions, Genetic
/
Telomere
/
Telomerase
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Genetic Association Studies
/
Republic of Korea
/
Telomere Homeostasis
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS