Allopurinol-induced DRESS syndrome mimicking biliary obstruction
Clinical and Molecular Hepatology
;
: 71-75, 2014.
Article
in English
| WPRIM
| ID: wpr-18373
ABSTRACT
An 84-year-old man was admitted to our hospital with fever, jaundice, and itching. He had been diagnosed previously with chronic renal failure and diabetes, and had been taking allopurinol medication for 2 months. A physical examination revealed that he had a fever (38.8degrees C), jaundice, and a generalized maculopapular rash. Azotemia, eosinophilia, atypical lymphocytosis, elevation of liver enzymes, and hyperbilirubinemia were detected by blood analysis. Magnetic resonance cholangiography revealed multiple cysts similar to choledochal cysts in the liver along the biliary tree. Obstructive jaundice was suspected clinically, and so an endoscopic ultrasound examination was performed, which ruled out a diagnosis of obstructive jaundice. The patient was diagnosed with DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) syndrome due to allopurinol. Allopurinol treatment was stopped and steroid treatment was started. The patient died from cardiac arrest on day 15 following admission.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biliary Tract
/
Bilirubin
/
Biliary Tract Diseases
/
Tomography, X-Ray Computed
/
Allopurinol
/
Magnetic Resonance Angiography
/
Endosonography
/
Creatine
/
Eosinophils
/
Drug Hypersensitivity Syndrome
Limits:
Aged
/
Aged80
/
Humans
/
Male
Language:
English
Journal:
Clinical and Molecular Hepatology
Year:
2014
Type:
Article
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