Cellular Density Evaluation for Malignant Lymphoma Using Equivalent Cross-Relaxation Rate Imaging - Initial Experience
Korean Journal of Radiology
; : 327-332, 2010.
Article
in En
| WPRIM
| ID: wpr-183836
Responsible library:
WPRO
ABSTRACT
OBJECTIVE: Equivalent cross-relaxation rate (ECR) imaging is an MRI technique used to evaluate quantitatively a change in the protein-water interaction. We aimed to evaluate retrospectively the usefulness of ECR imaging for the histologic classification of malignant lymphoma (ML). MATERIALS AND METHODS: Institutional Review Board approval was obtained and all patients provided informed consent. The study subjects included 15 patients with untreated ML who were histologically diagnosed with follicular lymphoma (FL; n = 8) or diffuse large B-cell lymphoma (DLBCL; n = 7). All patients underwent ECR imaging and the offset frequency was set at 7 ppm. RESULTS: The median ECR values were 71% (range; 60.7 to 75.5) in FL and 54% (50.8 to 59.4) in DLBCL (p = 0.001). The median cellular density was 1.5 +/- 0.17 x 10(6) / mm2 in FL and 1.0 +/- 0.70 x 10(6) / mm2 in DLBCL (p = 0.001). The correlation coefficient between the ECR values and cellular density in ML was 0.88 (p = 0.001). In FL and DLBCL, assuming ECR value cut-off points of 60%, both sensitivity and specificity were 100%. CONCLUSION: A strong correlation between ECR and cellular density in ML is demonstrated and the ECR may be a useful technique to differentiate between FL and DLBCL.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Observer Variation
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Cell Count
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Retrospective Studies
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Lymphoma, Follicular
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Lymphoma, Large B-Cell, Diffuse
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Imaging, Three-Dimensional
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Diffusion Magnetic Resonance Imaging
Type of study:
Observational_studies
Limits:
Adult
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Aged
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Female
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Humans
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Male
Language:
En
Journal:
Korean Journal of Radiology
Year:
2010
Type:
Article