Comparison of Premixed NaHCO3 and Lidocaine on Rocuronium Injection Pain / 대한마취과학회지
Korean Journal of Anesthesiology
; : 483-488, 2005.
Article
in Ko
| WPRIM
| ID: wpr-18428
Responsible library:
WPRO
ABSTRACT
BACKGROUND: Rocuronium administration is associated with a severe burning pain during injection in 50-80% patients. The purpose of this study was to evaluate mixtures of saline, lidocaine, sodium bicarbonate (NaHCO3) and lidocaine-NaHCO3 with rocuronium to reduce injection pain and withdrawal movement. METHODS: One hundred and twenty patients were randomly assigned to one of four groups in a double blinded, prospective study; Group S (0.9% normal saline 5 ml mixed with rocuronium 50 mg/5 ml, n = 30), Group L (2% lidocaine 5 ml mixed with rocuronium 50 mg/5 ml, n = 30), Group B (8.4% NaHCO3 5 ml mixed with rocuronium 50 mg/5 ml, n = 30) and Group LB (4% lidocaine 2.5 ml and 8.4% NaHCO3 2.5 ml mixed with rocuronium 50 mg/5 ml, n = 30). After all patients had received an intubating dose (0.6 mg/kg) of premixed rocuronium over 5 seconds, we investigated the incidence and severity of pain and withdrawal movement. We measured the onset and duration of muscle relaxation using train-of-four (TOF) and the pH values and osmolalities of each mixture. RESULTS: The incidence and severity of pain during injection were significantly reduced in Groups B and LB compared with Group S. The withdrawal movement was observed 8 patients (26.7%) in Group S, but in no patient in Groups B or LB. No significant difference in the incidence of pain or withdrawal response was observed between Groups S and L. CONCLUSIONS: We conclude that premixed NaHCO3 with rocuronium is effective at reducing injection pain and withdrawal movement whereas the addition of lidocaine has little effect.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Osmolar Concentration
/
Burns
/
Incidence
/
Prospective Studies
/
Sodium Bicarbonate
/
Hydrogen-Ion Concentration
/
Lidocaine
/
Muscle Relaxation
Type of study:
Incidence_studies
/
Observational_studies
/
Prognostic_studies
Limits:
Humans
Language:
Ko
Journal:
Korean Journal of Anesthesiology
Year:
2005
Type:
Article