Dexrazoxane for Preventing Anthracycline Cardiotoxicity in Children with Solid Tumors
Journal of Korean Medical Science
; : 1336-1342, 2010.
Article
in En
| WPRIM
| ID: wpr-187908
Responsible library:
WPRO
ABSTRACT
This study attempted to assess the incidence and outcome of anthracycline cardiotoxicity and the role of dexrazoxane as a cardioprotectant in childhood solid tumors. The dexrazoxane group included 47 patients and the control group of historical cohort included 42. Dexrazoxane was given in the 10:1 ratio to doxorubicin. Fractional shortening and systolic and diastolic left ventricular diameters were used to assess the cardiac function. The median follow-ups were 54 months in the dexrazoxane group and 86 months in the control group. The mean cumulative doses of doxorubicin were 280.8+/-83.4 mg/m2 in the dexrazoxane group and 266.1+/-75.0 mg/m2 in the control group. The dexrazoxane group experienced significantly fewer cardiac events (27.7% vs. 52.4%) and less severe congestive heart failure (6.4% vs. 14.3%) than the control group. Thirteen cardiotoxicities including one cardiac death and 2 congestive heart failures occurred in the dexrazoxane group, and 22 cardiotoxicities including 2 cardiac deaths and 4 congestive heart failures, in the control group. Five year cardiac event free survival rates were 69.2% in the dexrazoxane group and 45.8% in the control group (P=0.04). Dexrazoxane reduces the incidence and severity of early and late anthracycline cardiotoxicity in childhood solid tumors.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Razoxane
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Echocardiography
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Cardiovascular Agents
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Doxorubicin
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Cohort Studies
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Follow-Up Studies
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Ventricular Function, Left
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Disease-Free Survival
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Heart Failure
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Antibiotics, Antineoplastic
Type of study:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limits:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2010
Type:
Article