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Molecular Epidemiologic Analysis of Methicillin-Resistant Staphylococcus aureus Isolates from Bacteremia and Nasal Colonization at 10 Intensive Care Units: Multicenter Prospective Study in Korea
Article in En | WPRIM | ID: wpr-190744
Responsible library: WPRO
ABSTRACT
We investigated molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) isolated at 10 intensive care units (ICUs) in Korea. MRSA isolates from bacteremia and nasal colonization were collected prospectively from October 2008 through May 2009 at 10 University-affiliated hospital ICUs. A total of 83 and 175 MRSA strains were isolated from bacteremia and nasal colonization, respectively. Acquired group accounted for 69.9% (n = 58) of bacteremia and 73.1% (n = 128) of nasal colonization. Pulsed-field gel electrophoresis (PFGE) type B (SCCmec type II/ST5) was dominant in the acquired group followed by PFGE type D (SCCmec type IVA/ST72; a community genotype). Seven of 58 (12.1%) acquired bacteremia and 15 of 128 (11.8%) acquired nasal colonizations had SCCmec type IVA/ST72 genotype, which indicated that the community genotype had already emerged as a cause of ICU acquired MRSA infection or colonization. Antibiotic resistance rates to ciprofloxacin, tetracycline, clindamycin and trimethoprim/sulfamethoxazole were 84.4%, 67.1%, 78.1%, and 12.0%, respectively. Susceptibility to ciprofloxacin best predicted a community genotype (sensitivity 96.5%; specificity 96.9%; odds ratio 861; 95% confidence interval 169-4,390, P < 0.001) and the positive predictive value was 90.2%. Among 23 nasal re-colonized strains, 7 MRSA strains (30.4%) were different from the originally colonized strains on the basis of PFGE types.
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Full text: 1 Index: WPRIM Main subject: Staphylococcal Infections / Microbial Sensitivity Tests / Cross Infection / Prospective Studies / Electrophoresis, Gel, Pulsed-Field / Bacteremia / Nasal Lavage Fluid / Molecular Epidemiology / Drug Resistance, Multiple, Bacterial / Methicillin-Resistant Staphylococcus aureus Type of study: Clinical_trials / Observational_studies Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Country/Region as subject: Asia Language: En Journal: Journal of Korean Medical Science Year: 2011 Type: Article
Full text: 1 Index: WPRIM Main subject: Staphylococcal Infections / Microbial Sensitivity Tests / Cross Infection / Prospective Studies / Electrophoresis, Gel, Pulsed-Field / Bacteremia / Nasal Lavage Fluid / Molecular Epidemiology / Drug Resistance, Multiple, Bacterial / Methicillin-Resistant Staphylococcus aureus Type of study: Clinical_trials / Observational_studies Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Country/Region as subject: Asia Language: En Journal: Journal of Korean Medical Science Year: 2011 Type: Article