Metabolic Syndrome Is Associated with Delayed Heart Rate Recovery after Exercise
Journal of Korean Medical Science
; : 621-626, 2006.
Article
in En
| WPRIM
| ID: wpr-191671
Responsible library:
WPRO
ABSTRACT
Heart rate (HR) recovery after exercise is a function of vagal reactivation, and its impairment is a predictor of overall mortality and adverse cardiovascular events. While metabolic syndrome is associated with sympathetic overactivity, little is known about the relationship between metabolic syndrome and HR recovery. A symptom-limited exercise stress test in healthy subjects (n=1, 434) was used to evaluate HR recovery. Metabolic syndrome was defined according to the National Cholesterol Education Program's Adult Treatment Panel III (NCEP ATP-III) criteria. Seventeen percent of subjects had > or =3 criteria for metabolic syndrome. HR recovery was lower in men than women and in smokers than nonsmokers. The subject with metabolic syndrome (vs. without) showed lower HR recovery (10.3+/-11.6 vs. 13.6+/-9.7 per minute) and higher resting HR (64.3+/-10.3 vs. 61.6+/-9.1 per minute). HR recovery correlated inversely to age (r=-0.25, p<0.0001), but not to resting HR or maximal oxygen uptake. Delayed HR recovery was associated with metabolic syndrome after an adjustment for age, sex, resting HR and smoking (p<0.01). Metabolic syn-drome is associated with impaired vagal reactivation. Adverse cardiovascular out-comes associated with metabolic syndrome may be mediated by the failure of vagal reactivation in addition to sympathetic overactivity.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Oxygen Consumption
/
Blood Glucose
/
Blood Pressure
/
Exercise
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Smoking
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Body Mass Index
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Sex Factors
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Analysis of Variance
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Walking
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Age Factors
Type of study:
Prognostic_studies
Limits:
Adult
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Female
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Humans
/
Male
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2006
Type:
Article