Beneficial Effect of Lespedeza cuneata (G. Don) Water Extract on Streptozotocin-induced Type 1 Diabetes and Cytokine-induced Beta-cell Damage
Natural Product Sciences
; : 175-179, 2016.
Article
in En
| WPRIM
| ID: wpr-192321
Responsible library:
WPRO
ABSTRACT
The aim of this study was to evaluate the anti-diabetic effects of the water extract of Lespedeza cuneata (LCW) using rat insulinoma (RIN) m5F cells and streptozotocin (STZ)-induced diabetic rats. The effect of LCW on the protection of pancreatic beta cells was assessed using MTT assay, and nitric oxide production was assessed using Griess reagent. STZ-induced diabetic rats were treated with 100 and 400 mg/kg body weight of LCW for 5 weeks. In results, LCW significantly protected cytokine-induced toxicity and NO production, and increased insulin secretion in RINm5F cells. LCW significantly decreased serum blood glucose, thiobarbituric acid reactive substances (TBARS), blood urea nitrogen (BUN) and advanced glycation end products (AGEs) levels, and renal fibronectin expression in STZ-induced diabetic rats. Also, LCW effectively improved BW loss in STZ-induced diabetic rats. Thus, our results suggest that LCW has a beneficial effect on cytokine-induced pancreatic beta cell damage and biomarkers of diabetic complication in hyperglycemic rats.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Blood Glucose
/
Blood Urea Nitrogen
/
Body Weight
/
Water
/
Biomarkers
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Cytokines
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Fibronectins
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Thiobarbituric Acid Reactive Substances
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Streptozocin
/
Lespedeza
Limits:
Animals
Language:
En
Journal:
Natural Product Sciences
Year:
2016
Type:
Article