Strategy for Maximizing Therapeutic Efficacy of Adult Stem Cells / 한양의대학술지
Hanyang Medical Reviews
; : 159-162, 2012.
Article
in Ko
| WPRIM
| ID: wpr-192558
Responsible library:
WPRO
ABSTRACT
Stem cells have been suggested for the treatment of intractable neurological diseases. In spite of numerous clinical trials using autologous mesenchymal stem cells (MSCs), unfortunately, clinical efficacy has not yet been proved except for its safety. Although there are several reasons for unsuccessful efficacy of stem cell therapy using adult stem cells, we should consider the exact factors that may improve the therapeutic efficacy of adult stem cells. One of the most important factors is the patient's age when MSCs are obtained from patients. It is associated with decreased functions of MSCs. Several reports have shown that MSCs from elderly persons have decreased capacities in the secretion of neurotrophic factors and migration to the lesion site. Therefore, procedures potentiating MSCs need to be studied during ex-vivo expansion. To suggest diverse procedures to improve capacities of MSCs for improvement of therapeutic efficacy, I will discuss previously reported methods potentiating MSCs and will suggest further experiments.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Stem Cells
/
Neurodegenerative Diseases
/
Adult Stem Cells
/
Mesenchymal Stem Cells
/
Cell- and Tissue-Based Therapy
/
Nerve Growth Factors
Limits:
Adult
/
Aged
/
Humans
Language:
Ko
Journal:
Hanyang Medical Reviews
Year:
2012
Type:
Article