Isolation of a Klebsiella pneumoniae Isolate of Sequence Type 258 Producing KPC-2 Carbapenemase in Korea / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
; : 298-301, 2011.
Article
in En
| WPRIM
| ID: wpr-19300
Responsible library:
WPRO
ABSTRACT
Carbapenem-resistant Klebsiella pneumoniae isolates producing K. pneumoniae carbapenemases (KPC) were first reported in the USA in 2001, and since then, this infection has been reported in Europe, Israel, South America, and China. In Korea, the first KPC-2-producing K. pneumoniae sequence type (ST) 11 strain was detected in 2010. We report the case of a patient with a urinary tract infection caused by KPC-2-producing K. pneumoniae. This is the second report of a KPC-2-producing K. pneumoniae infection in Korea, but the multilocus sequence type was ST258. The KPC-2-producing isolate was resistant to all tested beta-lactams (including imipenem and meropenem), amikacin, tobramycin, ciprofloxacin, levofloxacin, and trimethoprim-sulfamethoxazole, but was susceptible to gentamicin, colistin, polymyxin B, and tigecycline. The KPC-2-producing isolate was negative to phenotypic extended-spectrum beta-lactamase (ESBL) and AmpC detection tests and positive to modified Hodge test and carbapenemase inhibition test with aminophenylboronic acid.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Bacterial Proteins
/
Urinary Tract Infections
/
Beta-Lactamases
/
Microbial Sensitivity Tests
/
Carbapenems
/
Sequence Analysis, DNA
/
Drug Resistance, Bacterial
/
Republic of Korea
/
Klebsiella pneumoniae
Limits:
Aged
/
Female
/
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
The Korean Journal of Laboratory Medicine
Year:
2011
Type:
Article