In Vitro Activity of Tigecycline Against Orientia tsutsugamushi
Yonsei Medical Journal
; : 1034-1037, 2016.
Article
in En
| WPRIM
| ID: wpr-194120
Responsible library:
WPRO
ABSTRACT
Scrub typhus is a zoonosis caused by Orientia tsutsugamushi (O. tsutsugamushi) occurring mainly in autumn in Korea. The need of new antibiotics has arisen with a report on strains resistant to antibiotics and chronic infection. This study aims to identify susceptibility of tigecycline in-vitro as a new therapeutic option for O. tsutsugamushi. Antibacterial activity of tigecycline against the O. tsutsugamushi was compared with doxycycline using flow cytometry assay. The inhibitory concentration 50 (IC50) was 3.59×10(-3) µg/mL in doxycycline-treated group. Whereas in 0.71×10(-3) µg/mL tigecycline-treated group. These findings indicate that tigecycline may be a therapeutic option for the treatment of scrub typhus.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Orientia tsutsugamushi
/
Scrub Typhus
/
Inhibitory Concentration 50
/
Drug Resistance, Bacterial
/
Minocycline
/
Anti-Bacterial Agents
Limits:
Humans
Language:
En
Journal:
Yonsei Medical Journal
Year:
2016
Type:
Article