Kinetin inhibits apoptosis of aging spleen cells induced by D-galactose in rats
Journal of Veterinary Science
; : 353-359, 2014.
Article
in En
| WPRIM
| ID: wpr-194863
Responsible library:
WPRO
ABSTRACT
Kinetin (Kn) is a cytokinin growth factor that exerts several anti-aging and antioxidant effects on cells and organs. To investigate the mechanism underlying apoptotic events in aging cells induced by D-galactose (D-gal), we examined the effect of Kn delivered via nuchal subcutaneous injection on D-gal-induced aging and apoptosis in rats. Our results showed that interleukin (IL)-2 levels and mitochondrial membrane potential (DeltaPsim) were decreased by Kn in aging rats while IL-6 production and apoptosis increased. In addition, the expression of anti-apoptotic Bcl-2 was low while that of Bax was high in the aging group. After treated with Kn, compared with aging group, there showed obvious difference in Kn group with elevated IL-2, proliferation index, Bcl-2, DeltaPsim and decreased IL-6 and Bax in splenic lymphocyte. Based on these results, we concluded that Kn can effectively protect the rat spleen from aging, apoptosis, and atrophy.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Spleen
/
Aging
/
Interleukins
/
Interleukin-6
/
Apoptosis
/
Membrane Potential, Mitochondrial
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Galactose
/
Kinetin
Limits:
Animals
Language:
En
Journal:
Journal of Veterinary Science
Year:
2014
Type:
Article