Phosphodiesterase 4D Gene and Risk of Noncardiogenic Ischemic Stroke in a Korean Population
Journal of Korean Medical Science
; : 307-310, 2009.
Article
in En
| WPRIM
| ID: wpr-198889
Responsible library:
WPRO
ABSTRACT
Recently published studies from different populations provide apparently conflicting evidence on the association between the phosphodiesterase 4D (PDE4D) gene and ischemic stroke. The relationship between a representative PDE4D genotype and ischemic stroke was explored in a case-control study of 205 consecutive Korean patients with noncardiogenic ischemic stroke and 103 healthy controls who were neurologically and radiologically proven to be stroke-free. We selected and genotyped a PDE4D single nucleotide polymorphism (SNP 41, rs152312) as a candidate marker for susceptibility to ischemic stroke because SNP 41 has shown the most significant association with stroke in both a meta-analysis and the original Icelandic study of the PDE4D gene. No significant difference was observed between the cases and controls in the distribution of the PDE4D SNP 41 genotypes. The results from the adjusted conditional logistic regression analysis (adjusted for age, hypertension, diabetes and smoking status) showed no significant association between PDE4D SNP 41 genotypes and an increased risk of noncardiogenic ischemic stroke. The PDE4D gene is not a major risk factor for noncardiogenic ischemic stroke in a Korean population, which supports the recent evidence suggesting that the causative genetic variants of ischemic stroke may differ across populations.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Magnetic Resonance Imaging
/
Case-Control Studies
/
Odds Ratio
/
Brain Ischemia
/
Risk
/
Regression Analysis
/
Magnetic Resonance Angiography
/
Genetic Predisposition to Disease
/
Stroke
/
Polymorphism, Single Nucleotide
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2009
Type:
Article