Successful treatment of tubulointerstitial nephritis and uveitis with steroid and azathioprine in a 12-year-old boy / 소아과
Korean Journal of Pediatrics
; : S99-S102, 2016.
Article
in En
| WPRIM
| ID: wpr-201850
Responsible library:
WPRO
ABSTRACT
Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease, often underdiagnosed or misdiagnosed in children. We describe the case of a 12-year-old boy who presented to Severance Hospital with a 1-month history of bilateral conjunctival injection. He was first evaluated by an Ophthalmologist in another hospital and diagnosed with panuveitis. Laboratory tests indicated renal failure, and a renal biopsy confirmed the diagnosis of acute tubulointerstitial nephritis. An extensive exclusion of all possible causes allowed a diagnosis of TINU syndrome. The patient was treated with a systemic corticosteroid (initially prednisolone, 2 mg/kg and later deflazacort 1 mg/kg) and topical steroid drops for 1 month. Azathioprine was later added to the treatment regimen and the systemic steroid was slowly tapered. The final outcome of renal-ocular disease was favorable in the patient. However, long-term follow-up is necessary to properly manage frequent relapses and incomplete renal recovery. TINU should be considered as a differential diagnosis in children with uveitis or acute renal failure.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Recurrence
/
Steroids
/
Azathioprine
/
Uveitis
/
Biopsy
/
Prednisolone
/
Panuveitis
/
Follow-Up Studies
/
Rare Diseases
/
Diagnosis
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limits:
Child
/
Humans
/
Male
Language:
En
Journal:
Korean Journal of Pediatrics
Year:
2016
Type:
Article