Antiretroviral Genotypic Resistance Mutations in HIV-1 Infected Korean Patients with Virologic Failure
Journal of Korean Medical Science
; : 1031-1037, 2009.
Article
in En
| WPRIM
| ID: wpr-203393
Responsible library:
WPRO
ABSTRACT
Resistance assays are useful in guiding decisions for patients experiencing virologic failure (VF) during highly-active antiretroviral therapy (HAART). We investigated antiretroviral resistance mutations in 41 Korean human immunodeficiency virus type 1 (HIV-1) infected patients with VF and observed immunologic/virologic response 6 months after HAART regimen change. Mean HAART duration prior to resistance assay was 45.3+/-27.5 months and commonly prescribed HAART regimens were zidovudine/lamivudine/nelfinavir (22.0%) and zidovudine/lamivudine/efavirenz (19.5%). Forty patients (97.6%) revealed intermediate to high-level resistance to equal or more than 2 antiretroviral drugs among prescribed HAART regimen. M184V/I mutation was observed in 36 patients (87.7%) followed by T215Y/F (41.5%) and M46I/L (34%). Six months after resistance assay and HAART regimen change, median CD4+ T cell count increased from 168 cells/microliter (interquartile range [IQR], 62-253) to 276 cells/microliter (IQR, 153-381) and log viral load decreased from 4.65 copies/mL (IQR, 4.18-5.00) to 1.91 copies/mL (IQR, 1.10-3.60) (P<0.001 for both values). The number of patients who accomplished viral load <400 copies/mL was 26 (63.4%) at 6 months follow-up. In conclusion, many Korean HIV-1 infected patients with VF are harboring strains with multiple resistance mutations and immunologic/virologic parameters are improved significantly after genotypic resistance assay and HAART regimen change.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Biological Assay
/
HIV Infections
/
HIV-1
/
Treatment Outcome
/
Viral Load
/
Antiretroviral Therapy, Highly Active
/
Drug Resistance, Viral
/
Mutation
Type of study:
Prognostic_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2009
Type:
Article