The Efficacy of Epinephrine-Containing Test Dose during Propofol-Nitrous Oxide Anesthesia with High Dose Fentanyl / 대한마취과학회지
Korean Journal of Anesthesiology
; : 411-414, 2006.
Article
in Ko
| WPRIM
| ID: wpr-205615
Responsible library:
WPRO
ABSTRACT
BACKGROUND: The aim of this study is to determine the effect of high dose fentanyl on the test dose containing 15microgram epinephrine during propofol anesthesia. METHODS: One hundred patients with ASA physical status 1 were randomized to receive 2 mg/kg propofol with or without 10microgram/kg fentanyl at the induction of anesthesia (n = 50 each). Anesthesia was maintained with propofol 8 mg/kg/h and 67% nitrous oxide in oxygen. Each group of patients were further divided into a test dose group receiving 1.5% lidocaine 3 ml plus epinephrine 15microgram or a saline group receiving 3 ml of isotonic saline (n = 25 each). Heart rate (HR) and systolic blood pressure (SBP) were monitored for 4 min after intravenous injection of the study drugs. RESULTS: In the propofol and the propofol-fentanyl group, the intravenous injection of the test dose produced a HR increase > or = 20 bpm (conventional HR criterion) in 25 and 23 out of the total 25 patients, respectively. Therefore, in the propofol-fentanyl group, sensitivity, specificity, positive predictive value, and negative predictive value were 82%, 100%, 100%, and 92.6%. According to the modified HR criterion (HR increase > or = 10 bpm), all the values were 100%. All patients receiving test dose developed SBP increase > or = 15 mmHg. CONCLUSIONS: Our results indicate that both HR increase > or = 10 bpm or SBP increase > or = 15 mmHg are clinically applicable during propofol-nitrous oxide anesthesia with 10microgram/kg fentanyl.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Oxygen
/
Blood Pressure
/
Epinephrine
/
Propofol
/
Fentanyl
/
Sensitivity and Specificity
/
Heart Rate
/
Injections, Intravenous
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Anesthesia
/
Lidocaine
Type of study:
Clinical_trials
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Diagnostic_studies
/
Prognostic_studies
Limits:
Humans
Language:
Ko
Journal:
Korean Journal of Anesthesiology
Year:
2006
Type:
Article