Circulating Concentrations of C-Peptide and Colorectal Adenoma
Clinical Nutrition Research
; : 17-23, 2014.
Article
in En
| WPRIM
| ID: wpr-206468
Responsible library:
WPRO
ABSTRACT
Hyperinsulinemia may increase the risk of colorectal neoplasia because of its mitogenic and antiapoptotic properties, which have a growth-promoting effect. We examined the association between circulating concentrations of C-peptide, a biomarker of insulin secretion, and colorectal adenoma prevalence in a case-control study of Korean adults. A total of 364 participants (112 cases and 252 controls) were included. Participants who underwent a colonoscopy completed questionnaires and provided blood samples. We used multivariate logistic regression models to obtain odds ratios (ORs) and 95% confidence intervals (CIs) for colorectal adenoma. Circulating concentrations of C-peptide were not associated with colorectal adenoma; the multivariate OR (95% CI) was 0.95 (0.51-1.75) comparing the highest tertile with the lowest tertile (p for trend = 0.91). When we used a conditional logistic regression model by fasting status and sex matching, there was still no association (OR = 0.92; 95% CI = 0.43-1.99) when comparing the highest tertile with the lowest tertile. We observed no association between circulating concentrations of C-peptide and colorectal adenoma prevalence in Korean adults.
Key words
Full text:
1
Index:
WPRIM
Main subject:
C-Peptide
/
Adenoma
/
Case-Control Studies
/
Logistic Models
/
Odds Ratio
/
Prevalence
/
Surveys and Questionnaires
/
Colonoscopy
/
Fasting
/
Hyperinsulinism
Type of study:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
Limits:
Adult
/
Humans
Language:
En
Journal:
Clinical Nutrition Research
Year:
2014
Type:
Article