A Study of the Effect of a Mixture of Hyaluronic Acid and Sodium Carboxymethyl Cellulose (Guardix-sol(R)) on the Prevention of Pericardial Adhesion / 대한흉부외과학회지
The Korean Journal of Thoracic and Cardiovascular Surgery
; : 596-601, 2010.
Article
in Ko
| WPRIM
| ID: wpr-207001
Responsible library:
WPRO
ABSTRACT
BACKGROUND: This study was designed to evaluate the efficacy of a mixture of hyaluronic acid and sodium carboxymethyl cellulose (Guardix-sol(R)) on experimental pericardial adhesion. MATERIAL AND METHOD: Thirty rats were divided into 2 groups of 15 rats each and pericardial mesothelial injury was induced during surgery by abrasion. In the control group, blood and normal saline were administered into pericardium; in the test group, blood and HA-CMC solution were administered. Pericardial adhesions were evaluated at 2 weeks (n=5), 4 weeks (n=5), and 6 weeks (n=5) after surgery. The severity of adhesions was graded by macroscopic examination, and the adhesion tissue thickness was analyzed microscopically with Masson trichrome stain and an image processing program. RESULT: The test group had significantly lower macroscopic adhesion scores (2.9+/-0.6 : 3.9+/-0.4, p<0.000) compared with the control group. For microscopic adhesion tissue thickness, the test group had lower scores compared with the control group, but this difference was not statistically significant (91.73+/-49.91 : 117.67+/-46.4, p=0.106). CONCLUSION: We conclude that an HA-CMC solution (Guardix-sol(R)) reduces the formation of pericardial adhesions in this animal model.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Pericardium
/
Sodium
/
Azo Compounds
/
Carboxymethylcellulose Sodium
/
Eosine Yellowish-(YS)
/
Models, Animal
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Hyaluronic Acid
/
Methyl Green
Type of study:
Prognostic_studies
Limits:
Animals
Language:
Ko
Journal:
The Korean Journal of Thoracic and Cardiovascular Surgery
Year:
2010
Type:
Article