Malignant Transformation of Intrathoracic Ancient Neurilemmoma in a Patient without Von Recklinghausen's Disease
Journal of Korean Medical Science
; : 295-298, 2003.
Article
in En
| WPRIM
| ID: wpr-210095
Responsible library:
WPRO
ABSTRACT
Malignant transformation of a neurilemmoma is an exceedingly rare event. We describe a case of intrathoracic ancient neurilemmoma undergoing a malignant change in a 39-yr-old man. The patient presented with right flank and chest pain for several months. Plain radiography and CT scan of the chest showed a soft tissue mass lesion at the extrapleural space with erosion of surrounding ribs at the right basal lung area. The excised mass was encapsulated and measured 4.5 x 3.5 x 2.3 cm. The cut surface showed grayish-white and glistening with a focal cystic change and hemorrhage. Necrosis was not seen. Histologically, the tumor showed the features of classic neurilemmoma composed of the Antoni type A and B areas with perivascular hyalinization. In addition, obviously histo-logically malignant foci manifested by presence of markedly increased cellularity with fascicular arrangement, active mitotic activity, hyperchromasia, and gradual loss of original neurilemmomatous feature were noted.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Thoracic Neoplasms
/
Biomarkers, Tumor
/
Cell Transformation, Neoplastic
/
Neurofibromatosis 1
/
Diagnosis, Differential
/
Neurilemmoma
Type of study:
Diagnostic_studies
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2003
Type:
Article